Dr. Manskikh will come to us in the evening via Zoom and will talk about several current ideas in the fight against aging. November 3, 8pm Moscow time (12pm EST).

Over the past decades, an incalculable number of attempts have been made to restore the structure of mammalian organs by introducing stem cells into them after damage.

However, it turned out that such a procedure does not lead to full restoration. At the same time, it is known that in organs with parenchymatous cells capable of proliferation, in some cases, complete regeneration (restitution) is possible.

Analysis of such models allows us to conclude that the most important condition for the restoration of the histological structures of an organ (in the presence of a stem pool) is the preservation of collagen framework structures in it, which serve as "guide rails" for proliferating and differentiating cells.

An alternative condition for complete reconstruction of organ structures is the presence of a free “morphogenetic space” consisting of a gel-like matrix of the embryonic connective tissue type, which occurs during embryonic organogenesis or during complete regeneration in amphibians.

Approaches aimed at preserving framework structures or creating a “morphogenetic space” could radically improve the results of organ regeneration using both local and exogenous stem cells.